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I am looking for a master student who can do his/her master thesis here for 6 months, or an intern for 3-6 months.
Please see the project description below:
Protein-protein docking based on predicted interfaces
Introduction
Protein-protein interactions are fundamental as many proteins mediate their biological function through these interactions. Many important applications follow directly from the identification of protein interface residues, such as drug design, engineering of protein mimetics, elucidation of molecular pathways, and understanding of disease mechanisms. The identification of interface residues can also guide the docking process for building structural models of proteinprotein complexes. We have developed in-house methods and software to predict proteinprotein binding sites and the structures of complexes by protein-protein docking.
The Project
Extend, refine and validate the in-house methods and software to predict the structures of
protein-protein complexes using predictions of the interface regions. It is also possible to
develop new algorithms for interface prediction and protein-protein docking.
Requirement
Familiarity with protein structure analysis
Independent software development
Programming experience in C++ and script language (python or perl)
The Institute
EML Research gGmbH (http://www.eml-research.de) is a private research institute focusing on
Information Technology and its applications. EML Research aims to develop innovative
information processing systems that combine highly sophisticated technology with optimum
user-friendliness. At present there are four research groups at EML Research, working in the
fields of bioinformatics, databases for scientific applications, and computational linguistics.
EML Research gGmbH is located in the Heidelberg Villa Bosch and in an adjacent building.
The Villa Bosch, the former residence of Nobel Prize laureate Carl Bosch, was completely
renovated in 1997, and also houses the Klaus Tschira Foundation gGmbH, the EML GmbH, and
a number of external institutions.
The Molecular and Cellular Modeling (MCM) group works on the development and application
of computer-aided methods to predict and simulate biomolecular interactions. The focus is on
proteins and the computational approaches are mostly based on the three-dimensional structures
of macromolecules. Techniques cover a wide spectrum from interactive, web-based
visualization tools to molecular and Brownian dynamics simulations.
Contact
Dr. Rebecca Wade (Group Leader) Dr. Bingding Huang
Rebecca.Wade@eml-r.villa-bosch.de Bingding.huang@eml-r.villa-bosch.de
Molecular and Cellular Modelling Group
EML Research gGmbH
Schloß-Wolfsbrunnenweg 33
69118 Heidelberg
[ 本帖最后由 markero 于 2008-11-25 11:24 编辑 ] |
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